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The changes of mucosubstances in the duodenal mucosa of developing rats were investigated by conventional methods. On the 15 and 17 day-old fetal rat, neutral mucosubstances were observed in the stratified epithelium of the duodenum, whereas both neutral mucosubstances and sialomucins were demonstrated in the oligomucous cells un 17 day-old fetal rat. The brush border contained neutral mucosubstanees and sialomucins from 19 day-old fetal rat, and thereafter changed the properties as a mixture of neutral mucosubstances, sialomucins and weak sulfomucins. In the goblet cells, most cells showed a mixture of neutral mueosubstances and strong sulfomucins from 19 day-old fetal rat, but a few cells contained neutral ones only. The amount of neutral and acid mucosubstances increased in the goblet cell of both villi and crypt during the suckling period. However acid mucosubstances increased in the goblet cells of crypt during the weanling period. The Brunner´s gland contained neutral mucosubstances only From 21 day-old fetal rat, but From the end of suckling period, a few cells located deep gland region contained additional strong sulfomucins.
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